In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist. A prerequisite for an inverse agonist response is that the receptor must have a constitutive (also known as intrinsic or basal) level activity in the absence of any ligand. An a...
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http://en.wikipedia.org/wiki/Inverse_agonist
An inverse agonist is a drug which acts at the same receptor as that of an agonist, yet produces an opposite effect. Also called negative antagonists.
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http://www.chem.qmul.ac.uk/iupac/medchem/ix.html
(= reverse antagonist) Any ligand that binds to receptors and reduces the proportion in the active form. Has the opposite effects to an agonist and may actually reduce the background level of activity. Not the same as a partial agonist.
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http://www.encyclo.co.uk/visitor-contributions.php
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